chromosomally and anatomically normal fetuses with increased first trimester nuchal translucency conceived by icsi

nuchal translucency (nt) measurements in the first trimester screening between 11 and 14 weeks’ gestation are regarded as a clear marker for aneuploidies. the presence of a thickened nt, even if the karyotype is normal, can be associated with structural abnormalities. having an abnormal screening of nt, parents and physicians could face dilemma over abortion particularly in a case of ivf/icsi fetuses. measurement of the nt thickness combined with biochemical markers has a false-positive rate of 5%. hereby we present six cases of chromosomally normal fetuses with an increased nt thickness in the first trimester, a normal karyotype and normal follow-up scans, who had a good prognosis for a normal early childhood. this report may help increase the confidence of couples who are reluctant to terminate the pregnancy.